科研情况 |
专业：微生物与免疫学 研究方向： 1.沙门氏菌分离、鉴定及耐药性研究 探究沙门氏菌分离鉴定方法、沙门氏菌耐药表型及其与耐药基因的关系，阐明沙门氏菌耐药机制. 2.肝脏肿瘤免疫学 探究天然模式识别受体在肝癌转移中的作用及分子机制，为肝癌治疗提供理论依据. 主持项目： （1）国家自然科学基金青年科学基金项目—NLRP3炎症小体通过促进NK细胞功能抑制肝癌转移及机制研究（2019.1-2021.12） 代表性论文： 1.Xin Yu, Peixiang Lan, Xuben Hou, Qiuju Han, Nan Lu, Tao Li, Chenwei Jiao, Jian Zhang, Cai Zhang*, Zhigang Tian*. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1bproduction via suppressing NF-kB pathway and ROS production, Journal of Hepatology, 2017; 66(4):693-702. 2.Xin Yu#, Hongru Zhang#, Linyan Yu, Meifang Liu, Qiuju Han, Jian Zhang, Zhigang Tian, Cai Zhang*. Intestinal lamina propria CD4+T cells promote bactericidal activity of macrophages via galectin-9 and Tim-3 interaction duringSalmonella typhimuriuminfection. Infection and Immunity, 2018;86(8). 3.于馨，张彩*.炎症小体信号通路的负调控.生物化学与生物物理进展, 2014;41(1)：87-95. 4. Zhixia Zhou,Xin Yu, Jian Zhang, Zhigang Tian, Cai Zhang*.TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Letters, 2015; 369(2):298-306. 5. Qie Guo, Peixiang Lan,Xin Yu, Qiuju Han, Jian Zhang, Zhigang Tian, Cai Zhang*. Immunotherapy for hepatoma using a dual-function vector with both immunostimulatory and Pim-3-silencing effects. Molecular Cancer Therapeutics, 2014; 13(6):1503-1513. *通讯作者，#共第一作者. |
